Observations on Several Experimental Models of Hypertension in Mice

Abstract

A cuff and tail microphonic method (Friedman-Freed's technique) was applied to determine the systolic blood pressure of unanesthetized mice. It ranged from 94 to 132mm.Hg with a mean of 109mm.Hg. Chronic hypertension and hypertensive cardiovascular changes were induced in mice by a) constriction of unilateral renal artery with contralateral nephrectomy (Goldblatt), b) complete ligation of a branch of unilateral artery with contralateral nephrectomy (Loomis), c) unilateral adrenal enucleation with contralateral nephrectomy and adrenalectomy plus salt (Skelton), and by d) desoxycorticosterone acetate plus salt.