抄録
Twelve patients with stable angina pectoris received a placebo for 7 days and then oral phentolamine for an additional 7 days. Exercise was performed at the conclusion of the 2 drug periods. All of the patients developed angina with the stress of exercise while taking placebos. The average time to develop angina was 208sec. In comparison, 9 of the 12 patients were able to exercise longer after phentolamine. The mean increment in exercise capacity was 95sec. Four of the patients were limited by fatigue rather than by angina following phentolamine. None of the patients exercised less after phentolamine than after placebo. Phentolamine can be an effective agent in the treatment of angina pectoris.
