Anti-Heart Antibodies in Chronic Cor Pulmonale
1974 年 15 巻 3 号 p. 223-233
詳細
1974 年 15 巻 3 号 p. 223-233
In patient with chronic cor pulmonale which was caused by pul-monary emphysema, circulating autoantibodies against the heart tissue were investigated by hemagglutination and hemagglutination-inhibition techniques using normal rabbit's myocardium as antigen. Quantitative analysis of serum IgG, IgA and IgM were carried out by use of the radial immunodiffusion method. These results were compared with clinical findings, specifically cardiopulmonary hemodynamics and patho-physiological changes.
Circulating anti-heart antibodies were found in 13 out of 25 (52 per cent) patients with a definite complication of chronic cor pulmonale. The titers of circulating anti-heart antibodies indicated a good correla-tion with hypoxia and pulmonary hypertension and/or pulmonary circu-latory disturbance. Furthermore, a good correlation was noted between anti-heart antibody titers and the serum IgG levels.
These data could be utilized in evaluation and discussion of the pathophysiological findings of the patients with chronic cor pulmonale.
