抄録
Hemodynamic effects of dopamine were studied on 30 open-chest dogs with experimental myocardial infarction. These dogs were divided into 3 groups. Three different doses of intravenous dopamine, 5, 10, and 20μg/Kg/min, were administered for 30min. Heart rate and myocardial contractility were increased dose-dependently. Total peripheral vascular resistance was reduced with 5 or 10μg/Kg/min of dopamine. With 20μg/Kg/min of dopamine, it became the lowest 5min after the initiation of infusion but increased above the control value 20min after the start of administration. Renal vascular resistance was decreased with 5μg/Kg/min of dopamine but increased with 20μg/Kg/min.
These results suggested that this drug would be useful for treatment of shock state.
