Decreased Hepatic Δ4-Reductase Activity for Aldosterone in SHR

Keiji Mikami; Mikio Watanabe; Taira Takagi; Tetsuo Nishikawa; Kenichi Yamada; Yasushi Tamura; Masahiro Yamamoto; Akira Kumagai

doi:10.1536/ihj.20.707

Decreased Hepatic Δ⁴-Reductase Activity for Aldosterone in SHR

Keiji Mikami, Mikio Watanabe, Taira Takagi, Tetsuo Nishikawa, Kenichi Yamada, Yasushi Tamura, Masahiro Yamamoto, Akira Kumagai

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JOURNAL FREE ACCESS

1979 Volume 20 Issue 5 Pages 707

DOI https://doi.org/10.1536/ihj.20.707

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Abstract

Decrease in Δ⁴-reductase activity was observed in SHR at 15 and 20w of age, e.g., only when hypertension was established. Even if hypertension was corrected by fusaric acid (FA) administration, the decrease in Δ⁴-reductase activity was not reversed. Thus the decrease in Δ⁴-reductase in SHR might be caused by factors other than hypertension

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