抄録
The changes of left ventricular anatomy and function following treatment with antihypertensive agents for 1 to 2 years were studied by echocardiography in 34 patients with hypertension whose blood pressures and electrocardiographic voltages (SV1+RV5) were significantly decreased (p<0.001 and 0.01, respectively). The drugs administered or used were trichlormethiazide, β-blockers, α-methyldopa, clonidine hydrochloride, and guanethidine. Most patients received 2 or more of the above drugs.
The interventricular septal thickness, the left ventricular posterior wall thickness, the calculated left ventricular mass, the atrial dimensions, all decreased following treatment of hypertension for 1 to 2 years (p<0.001-0.05), and the ejection fraction improved (p<0.001). It is concluded that cardiac hypertrophy is not irreversible in patients with hypertension if their blood pressure is adequately controlled.
