抄録
Hypertension was augmented by Na-loading and attenuated by K-loading in SHRSP. These findings indicate that not only Na-restriction but also K-loading more actively reduces high blood pressure and may be effective in preventing hypertensive diseases. The attenuation of severe hypertension by K-loading was more marked in salt-sensitive SHRSP than in less salt-sensitive SHRSR. These experimental findings support our epidemiological study indicating that blood pressure is significantly correlated with urinary Na/K ratio in 1120 inhabitants of "one rural community" in Japan. Our experimental clinical attempts to reduce Na/K ratio by using low salt soy sauce (9% NaCl) or low salt soy sauce containing KCl (at NaCl to KCl ratio of 65 to 25) and table salt containing KCl (25%) in 12 healthy volunteers under strict medical observation for 3 weeks have confirmed that the reduction of Na/K ratio is effective in lowering systolic blood pressure significantly.
