抄録
The bead-like lesion in rat mesenteric artery occurred more frequent in old stroke-prone spontaneously hypertensive rats(SHRSP), aged over 8 months, and especially in male SHRSP than in female SHRSP or in older SHRSP than in old SHRSP, while it was very rare in older stroke-resistant SHH(SHRSR) and was not found in older Wistar Kyoto rats(WKY). The bead-like lesion was periarteritis nodosa microscopically. Electronmicroscopically, various cells such as endothelial cells, fibroblast-like cells and leucocytes showed the activated states; the well-developed Golgi apparatus and the dilated lumens of rough endoplasmic reticulum. In SHRSP of both sexes, aged 12-19.5 months, systolic blood pressure was higher in the cases with bead-like lesion than in the cases without it, and this finding was confirmed by the increment of heart weight. Therefore, high blood pressure is one factor to induce bead-like lesion in mesenteric artery.
