Experimental Studies on the Beriberi Heart
III. Correct Treatment Doses of Thiamine for the Beriberi Heart Disease and Effects of Vitacampher and Norepinephrine
1964 年 5 巻 2 号 p. 150-170
詳細
1964 年 5 巻 2 号 p. 150-170
As there is no definite standard on the treatment dosage of thiamine for beriberi heart we carried on experiments on thiamine deficient rats.
(1) Vitacampher and norepinephrine had hardly any effect on electrocardiographic changes.
(2) Each dose of thiamine showed marked effect until the 4th week of first-time thiamine deficiency but after the 5th week there was a difference in the effectiveness. Even a quite large dose had no effect on greatly emaciated rats in the final stage.
(3) From these findings, it became clear that thiamine effect is remarkable in the mainly functional disturbance stage but it is less effective in organic disturbance stage. That is, thiamine effect depends on the degree of myocardial lesions.
(4) We tried a new experimental method to study the treatment doses of thiamine for beriberi heart ; repetition method of thiamine deficiency and cure by single thiamine injection.
(5) There was hardly any noticeable difference between the curative effect of small dosage and of large dosage until the 3rd-time thiamine deficiency. However, after the 5th-time deficiency unless the dosage was as large as 0.2 to 0.5mg. (when calculated in terms of human dosage this amounts to several hundreds mg.) it had no curative effect.
(6) From the above experiments we were able to determine the following :
a) Small dosage of thiamine (several mg. to about 10mg. daily) is probably enough for mild or new beriberi heart.
b) For repeated chronic or severe beriberi heart quite large doses (several hundreds mg. a day) should be given parenterally immediately. Corresponding to the degree of improvement thiamine dosage can be gradually decreased to about several tens mg. daily.
c) For far advanced beriberi heart with great myocardial changes, any large doses of thiamine will have no effect.
