Fatty Acid Peroxides and Antioxidants in Rabbit Tissue

抄録

The present investigations were performed with rabbits, in order to know the changes of peroxides and antioxidants in the tissues in cholesterol-induced experimental atherosclerosis.
The content of non protein SH in the liver was not altered on 4th-week following cholesterol feeding. That of aorta tended to decrease on 4th-week and significantly decreased on 12th-month.
SDH activity in the liver was not different on 4th-week from that of the normal. That of aorta has a tendency to increase on 4th-week, but statistically not significant.
The content of thiobarbituric acid reactive substances in the liver and plasma was not changed on 4th-week and increased on 12th-month. That of aorta was already increased on 4th-week.
Free radicals were present in plasma, liver and aorta of the normal rabbit. ESR pattern of plasma, liver and aorta was not different among these tissues, and not altered by cholesterol feeding.