1998 Volume 4 Issue 1 Pages 33-41
In order to elucidate relation of five enzymes and the susceptibility of stomach cancer and cigarette-smoking, epidemiological studies is performed. We have accumulated the blood sample of the stomach cancer patients and healthy people and analyzed the gene identification by PCR method. There data are analyzed by several statistical methods, i.e., odds ratio calculations, chi-square calculation and logistic regression. From the analysis, we have confirmed a strong correlation of the gene GSTM1 with the stomach cancer. Both calculations of odds ratio and chi-square indicate that the gene is considered with over 95% reliability as an important gene for the stomach cancer. As for the effect of the other genes, the order ot the correlation is obtained as GSTM1 > GSTT1 > NAT1 > GSTP1 > NAT2 from both the odds ratio analysis an chi-square analysis. The analysis of the effect of cigarette smoking as an environmental factor gives a quite interesting result. The logistic regression analysis shows that the people who does not have the gene is easy to raise the susceptibility a little smoking. On the other hand, the susceptibility of the people who has the gene goes down by a little smoking.
