Multiple myeloma with high adenosine deaminase expression

Shingen NAKAMURA; Hirokazu MIKI; Masami IWASA; Akishige IKEGAME; Tomoko MARUHASHI; Ryohei SUMITANI; Munenori UEMURA; Mamiko TAKAHASHI; Asuka ODA; Shiro FUJII; Kumiko KAGAWA; Masahiro ABE

doi:10.57352/ijm.7.1_1

CASE REPORT

Multiple myeloma with high adenosine deaminase expression

Shingen NAKAMURA, Hirokazu MIKI, Masami IWASA, Akishige IKEGAME, Tomoko MARUHASHI, Ryohei SUMITANI, Munenori UEMURA, Mamiko TAKAHASHI, Asuka ODA, Shiro FUJII, Kumiko KAGAWA, Masahiro ABE

著者情報

Shingen NAKAMURA
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
Hirokazu MIKI
Division of Transfusion Medicine and Cell Therapy, Tokushima University Hospital, Tokushima, Japan
Masami IWASA
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
Akishige IKEGAME
Division of Medical Technology, Tokushima University Hospital, Tokushima, Japan
Tomoko MARUHASHI
Department of Internal Medicine, Local Incorporated Administrative Agency Tokushima prefecture Naruto hospital, Tokushima, Japan
Ryohei SUMITANI
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
Munenori UEMURA
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
Mamiko TAKAHASHI
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
Asuka ODA
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
Shiro FUJII
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
Kumiko KAGAWA
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan
Masahiro ABE
Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

キーワード: adenosine deaminase, multiple myeloma, pleural effusion

ジャーナルフリー

2017 年 7 巻 1 号 p. 1-5

DOI https://doi.org/10.57352/ijm.7.1_1

詳細

抄録

A 50-year-old man with immunoglobulin A type multiple myeloma (MM) was referred to our hospital after bortezomib therapy. He had high alkaline phosphatase and lactate dehydrogenase levels. Computed tomography showed osteolytic and osteoblastic bone lesions. Response to salvage chemotherapy was temporary, and he developed a right pleural effusion with high adenosine deaminase (ADA) levels. He died from bleeding associated with a pelvic bone fracture 9 months later. ADA mRNA expression and ADA secretion of the MM cells from the patient were higher than those from myeloma cell lines tested. Clinical relevance of high ADA expression in MM cells is warranted.

責任著者(Corresponding author)

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