Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271– 8587, Japan

Department of Pharmacology, and Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271– 8587, Japan

Department of Community Oral Health, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271– 8587, Japan

Nihon University Graduate School of Dentistry at Matsudo, Histology, Cytology and Developmental Anatomy, Matsudo, Chiba 271–8587, Japan

Nihon University Graduate School of Dentistry at Matsudo, Community Oral Health, Matsudo, Chiba 271–8587, Japan

Department of Community Oral Health, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271– 8587, Japan

Department of Community Oral Health, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271– 8587, Japan

Department of Community Oral Health, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271– 8587, Japan

Department of Community Oral Health, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271– 8587, Japan

Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271– 8587, Japan