抄録
Sodium hydride in polyethylene glycol has been used as a sustainable, non-volatile, and ecofriendly catalytic medium for the green synthesis of bisphosphonates with an alkyl/aryl/heterocyclic group fixed at the geminal carbon. All compounds (3a-j) were characterized by IR, 1H and 31P NMR, mass and elemental analysis. The easy recyclability of the reaction medium makes the reaction economically and potentially viable for commercial applications.
