Abstract
Both erythrocyte and hepatic delta-aminolevulinic acid dehydratase (ALA-D) activities were simultaneously determined on mice administered 0.02% (w/v) lead in the drinking water.
The ALA-D activity of erythrocytes was markedly depressed even at an early time of lead administration. On the other hand, the ALA-D activity of liver was not significantly inhibited until the termination of the lead administration. These data may suggest that the sensitivity of erythrocyte ALA-D to lead in vivo is dif-ferent from that of hepatic ALA-D, although the hepatic ALA-D activity had a significant correlation with the erythrocyte ALA-D activity (r=0.5532, p<0.001).
