Abstract
The present investigation reports on the topography of few enzymes viz-alkaline phosphatase, acid phosphatase, 5-nucleotidase and lipase in the kidney of rat, Rattus rattus albino after individual and combined treatments with molybdenum and copper. Molybdenum intake altered enzyme activities whereas total inhibition was caused by copper though lipase remained un-inhibited. Comparison of controls with the combined effects, revealed no appreciable difference in the topography of these en-zymes. Reversible dysenzymia thus observed points towards the conditioned metal ion antagonism and rapair in cellular membranes. Several hypothesises for their differential biochemical behaviour, cause & significance in enzymological patterns have been considered. Reversible dysenzymia has been explained on the basis that copper becomes unavailable through interaction with molybdate to form either cupric molybdate or copper thiomolybdate which is ultimately excreted.
