RELATIONSHIP BETWEEN PHYSICO-CHEMICAL PROPERTIES OF METAL CATIONS AND THEIR ACUTE LETHAL DOSES TO RABBIT, RAT AND MOUSE

Abstract

Relationship between acute lethal doses of various matal cations to rabbit, rat or mouse and their physico-cnemical properties was investigated in due consideration of binding strength between metal cations and biological important substances.
It was found that logarithm of the acute lethal dosesof metal cations decreased linearly with the increase of the following physico-chemical properties of metal cations; logarithm of stability constant of metal-EDTA chelate, product of electronegativity and ionic charge, and standard electrode potential.