SYNERGISTIC RESPONSE OF HYDROGEN PEROXIDE AEROSOLS AND SULFUR DIOXIDE TO PULMONARY AIRWAY RESISTANCE
1964 Volume 2 Issue 1 Pages 34-45
Details
1964 Volume 2 Issue 1 Pages 34-45
In 24 healthy volunteer males, changes of pulmonary airway resistance were measured in the following sequence of inhalation ; 1) after short term inhalation of hydrogen peroxide aerosols in two groups of 4.6μ and 1.8μ of their count median diameter, 2) sulfur dioxide (1-60 ppm), 3) mixture aerosols of hydrogen peroxide and sulfur dioxide, 4) bronchodilator, 5) the mixture aerosols of the same to 3), and their effects were compared with the preexperi-mental control level. A synergistic increase of the response was observed by the mixture aerosols which were recognized as sulfuric acid mist. Difference of the particle size resulted in different response to the respiratory tracts.
