Abstract
Chrysotile inoculated intratracheally into normal and BCG immunised guinea pigs incited a macrophage response and reticulin fibrosis. The immunised animals showed a more rapid localisation of pulmonary lesions and disappearance of the chrysotile fibres leading to accelerated focal fibrosis. More rapid transport of chrysotile to the lymph nodes of immunised animals was also observed. These findings suggest that BCG vaccine can influence the development of pathological lesions of asbestosis in guinea pigs by inducing them earlier and more rapidly.
