1982 Volume 20 Issue 4 Pages 283-296
The effects of di-isopropylnaphthalenes (KMC) and 1-phenyl-1-xylyl-ethanes (SAS) were examined in rats. The rats were administered 0.1 g of the substances per kg of body weight every day for a month. The substances were given directly into the stomach with a syringe. At about 2 hours efter receiving the final dosage, the rats were killed and examined biochemically. An increase in liver weight, disturbance of lipid metabolism in the liver and serum and disturbance of glucose metabolism in the liver were observed after the administration of KMC-A and SAS-296. A significant increase in alkaline phosphatase activity in the serum was noted only in the case of SAS-296 administration. A decrease in kidney weight was observed only after KMC-A administration. The results obtained in these animal experiment have clear implications for the health examination of workers who come in contact with KMC or SAS.
