Abstract
Daily oral administration of carbon tetrachloride (0.5 ml/kg/day) for a period of 15 days, followed by endosulfan (2.0 and 4.0 mg/kg/d), carbaryl (50 and 100 mg/kg/d) and phosphamidon (0.5 and 1.0 mg/kg/d) for 15 days to different groups of male rats triggered significant enzymatic changes. Whereas treatment of CCl4 alone for a period of 15 days (group 5) elicited altered morphology of hepatocytes and a highly significant increase in the activity of serum transaminases, alkaline phosphatase, bilirubin content and severe hypoglycemia, CCl4-insecticide treatment did not suggest a synergistic efiect of the two groups of agro industrial chemicals in experimental animals. On the contrary, the values of enzymatic activity and blood sugar in CCl4-insecticide exposed animals were nearer to those of normal. A significant inhibition of acetylcholinesterase activity of brain and red blood cell was seen after phosphamidon alone (group 4) and after CCl4-phosphamidon treat-ments (groups 10 and 11) which also support lack of synergistic efiect of CCl4-phosphamidon.
