Chelation in Metal Intoxication XV: Influence of Dimercaptopropane Sulphonate (DMPS) on Lead Poisoned Rats with Normal or Damaged Kidneys

Abstract

The efficacy of 2, 3 dimercaptopropane 1, sulphonate (DMPS) to enhance urinary excretion of lead, reduce the concentration of Pb in blood, brain, kidneys and liver and restore Pb induced alterations in the activities of renal and blood enzymes and brain biogenic amines in rats with normal or experimentally damaged kidneys, was investigated. The acute renal damage was induced by uranyl acetate prior to treatment with DMPS. The chelating agent was effective in reducing body burden of Pb by enhancing its excretion and in restoring biological altera-tions, more markedly in animals with normal kidneys than in those with acutely damaged kidneys. However, the increased brain concentration of Pb and altered levels of brain catecholamines remained unaffected on treatment with DMPS.