1985 Volume 23 Issue 2 Pages 145-153
To clarify the conditions and the mechanism of contact dermatitis from organophosphorus insecticides, case analysis of 202 patients with contact dermatitis from organophosphorus insecticides, who were collected from all over the country in cooperation with the members of the Japanese Association of Rural Medicine, and some related experiments were undertaken. The results were as follows:
1. From the case analysis, the solitary compounds of organophosphorus insecticides chiefly attributed to the dermatitis were DDVP, salithion, sumithion, phosvel, cyanox, kilval, diazinon and malathion in order.
2. The regions of the dermatitis were finger (62.4%), face (39.6%), forearm (31.7%), neck and nape (29.7%) and so forth.
3. About one quarters (25.2%) of the cases with the dermatitis had complicationwith symptoms of acute poisoning from organophosphorus compounds. The rates ofpatients ragarding the prognosis of the dermatitis were relatively high in healed cases (44.1%) and in treatment cases (27.2%), but about one fourth of the patients (23.8%) were left in incomplete healing.
4. From the animal experiment, relatively strong degree of primary irritating reactions on the skin of guinea pigs were observed especially in such insecticides as DDVP.
5. Potency of allergenicity predicted by the guinea pig maximization test was relatively high (grade III to V) for such organophosphorus compounds as diazinon, fenitrothion and supracide. Apparent cross reactions were observed between supracide and DDVP or dibrom, but they were lower in such cases between organophosphorus insecticides and other pesticide series as benzimidazole and carbamates.
