1986 Volume 24 Issue 1 Pages 1-14
Histopathological examination was carried out on male rats after single subcutaneous administration of 1, 2-dibromo-3-chloropropane (DBCP). DBCP produced injury in the kidney, testis, intestine, lympho-hematopoietic tissues, epididymis and liver. The renal injury consisted of proximal tubular necrosis in the outer medulla and degeneration of glomerular podocytes. Seminiferous epithelial desquamation and tubular atrophy were seen in testis. In lympho-hematopoietic tissues, there was depletion of lymphocytes as well as myeloid cells. Intestinal epithelial necrosis and rare mitosis occurred in the crypt of Lieberkiihn. Hepatic and epididymal injuries were relatively mild. The lesions developed dose-dependently, the minimal effective doses appearing to be 30 mg/kg for kidney, 100 mg/kg for testis, intestine and lympho-hematopoietic tissues and 300 mg/kg for epididymis and liver. These results indicated that DBCP might be a radiomimetic toxicant.