Industrial Health
Online ISSN : 1880-8026
Print ISSN : 0019-8366
ISSN-L : 0019-8366
Lead Acetate Induced Cytotoxicity in Male Germinal Cells of Swiss Mice
U.R. ACHARYAS. ACHARYAM. MISHRA
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JOURNAL FREE ACCESS

2003 Volume 41 Issue 3 Pages 291-294

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Abstract

Single intraperitoneal injection of lead acetate (200 mg/kg b.w) to Swiss mice stimulated testicular weight loss with a constant increase in the incidence of abnormal sperm population and decrease in the total sperm count. Testicular ascorbic acid also declined significantly during the post-treatment phase with significant rise in Lipid Peroxidation Potential (LPP) of the tissue. Elevated LPP is indicative of oxidative stress in treated mice testes. The possible role of lead-induced oxidative stress in culminating increased sperm abnormality and decreased sperm count have been discussed. Further, possible antioxidative role of testicular ascorbic acid in minimizing oxidative stress in leadtreated mice has been demonstrated.

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© National Institute of Occupational Safety and Health
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