抄録
The formation of heart is regulated by coordinated complex processes: cardiac progenitors migrate from both sides of the anterior lateral plate mesoderm toward the midline and differentiate into the heart tube including atrium and ventricle. Forward genetic analysis using zebrafish has identified several mutants defective in myocardial migration, resulting in two hearts known as cardia bifida. Identification of genes responsible for the cardia bifida mutations has revealed key players that regulate the migration and assembly of cardiac progenitors. Both anterior endoderm and the extraembryonic tissue yolk syncytial layer (YSL) provide for this process, thereby controlling the coordinated movement of cardiac progenitors. Further, the signaling pathway mediated by sphingosine 1-phosphate (S1P) is essential for the migration of cardiac progenitors in zebrafish.
