Role of sphingosine 1-phosphate signaling for the pathogenesis of autoimmune diseases

Tsuyoshi Iwasaki; Sachi Tsunemi; Sachie Kitano; Chieri Kanda; Masahiro Sekiguchi; Masayasu Kitano; Hajime Sano

doi:10.2492/inflammregen.31.175

Mini Review

Role of sphingosine 1-phosphate signaling for the pathogenesis of autoimmune diseases

Tsuyoshi Iwasaki, Sachi Tsunemi, Sachie Kitano, Chieri Kanda, Masahiro Sekiguchi, Masayasu Kitano, Hajime Sano

著者情報

キーワード: sphingosine 1-phospahte, FTY720, rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome

ジャーナルフリー

2011 年 31 巻 2 号 p. 175-183

DOI https://doi.org/10.2492/inflammregen.31.175

詳細

抄録

Sphingosine 1-phosphate (S1P) acts as an extracellular mediator by binding to G protein- coupled receptors, regulating cell proliferation, angiogenesis and inflammation. FTY720 (FTY) is a high-affinity agonist for S1P receptors, inducing internalization of receptors, rendering the cells unresponsive to S1P. Here, we review the role of S1P signaling for the pathogenesis of autoimmune diseases and the therapeutic effects of FTY on autoimmune diseases.

責任著者(Corresponding author)

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