Disease-associated iPS cell lines representing hematological and immunological disorders

抄録

Induced pluripotent stem cells (iPSCs) are potential cell sources for regenerative medicine and other clinical applications, such as cell therapies, drug screening, toxicology testing, and the investigation of disease mechanisms. Discovery of disease-associated iPSCs has led to the development of a new field of disease modeling, as they can provide somatic cells which cannot be directly obtained from each patient. In this review, we focus on the applications of disease-associated iPSCs for understanding human hematological and immunological disorders, while discussing the current state of hematopoietic differentiation and the findings of previous reports of disease-associated iPSCs in this field.