Unusual Skin Reactions after Mosquito Bites and Epstein-Barr Virus Reactivation in a Patient with Mantle Cell Lymphoma

Toshio SHIGEKIYO; Hiroko OHMORI; Masahito CHOHRAKU; Shinsaku OHTSUKA; Kazue YAMABE; Yoshihiro TAKISHITA; Shigeharu TAKAI; Masanori TAKAHASHI; Shingo WAKATSUKI

doi:10.2169/internalmedicine.43.986

Hematological Diseases

Unusual Skin Reactions after Mosquito Bites and Epstein-Barr Virus Reactivation in a Patient with Mantle Cell Lymphoma

Toshio SHIGEKIYO, Hiroko OHMORI, Masahito CHOHRAKU, Shinsaku OHTSUKA, Kazue YAMABE, Yoshihiro TAKISHITA, Shigeharu TAKAI, Masanori TAKAHASHI, Shingo WAKATSUKI

Author information

Toshio SHIGEKIYO
Department of Internal Medicine, Tokushima Prefectural Central Hospital
Hiroko OHMORI
Department of Internal Medicine, Tokushima Prefectural Central Hospital
Masahito CHOHRAKU
Department of Internal Medicine, Tokushima Prefectural Central Hospital
Shinsaku OHTSUKA
Department of Internal Medicine, Tokushima Prefectural Central Hospital
Kazue YAMABE
Department of Internal Medicine, Tokushima Prefectural Central Hospital
Yoshihiro TAKISHITA
Department of Internal Medicine, Tokushima Prefectural Central Hospital
Shigeharu TAKAI
Surgery, Tokushima Prefectural Central Hospital
Masanori TAKAHASHI
Pathology, Tokushima Prefectural Central Hospital
Shingo WAKATSUKI
Department of Pathology, Hyogo Prefectural Awaji Hospital

Keywords: Chronic active Epstein-Barr virus infection, Chronic Epstein-Barr virus infection, Epstein-Barr virus, Epstein-Barr virus reactivation, hypersensitivity to mosquito bites, mantle cell lymphoma

JOURNAL OPEN ACCESS

2004 Volume 43 Issue 10 Pages 986-989

DOI https://doi.org/10.2169/internalmedicine.43.986

Details

Abstract

We detected Epstein-Barr virus (EBV) reactivation in a patient with mantle cell lymphoma (MCL). The patient, a 53-year-old Japanese man, had been referred to our hospital because of generalized lymphadenopathy, hepatosplenomegaly and lymphocytosis and gave a history of intense skin reactions to mosquito bites. The biopsied lymph node contained a monotonous proliferation of medium-sized lymphocytes with scant cytoplasm and slightly irregular nuclei that were CD5⁺, CD20⁺ and CD23^-. Antibody titers of IgG against EBV viral capsid antigen and early antigen were increased, and EBV was detected in the lymphoma cells. This case may suggest a relationship between EBV and MCL.

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