Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Rheumatic Diseases
Microscopic Polyangiitis Associated with Diffuse Panbronchiolitis
Jangchul PARKShogo BANNOYoshiki SUGIURAKosho YOSHIKAWATaio NANIWAKaori WAKITAYoshihito HAYAMIShigeki SATORyuzo UEDA
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JOURNALS OPEN ACCESS

2004 Volume 43 Issue 4 Pages 331-335

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Abstract

There are several case reports of systemic vasculitis associated with chronic suppurative lung diseases. We describe a 46-year-old female, previously diagnosed as having diffuse panbronchiolitis (DPB), presenting with hemosputum and dyspnea. Her serum titer of MPO-ANCA was positive together with a high titer of BPI-ANCA. Chest X-ray and chest CT scan showed pulmonary hemorrhage, and the renal biopsy specimen revealed necrotizing, crescentic glomerulonephritis. She was diagnosed as having ANCA-associated vasculitis, and more specifically, microscopic polyangiitis accompanied by DPB. She was treated with methylprednisolone pulse therapy, followed by intravenous cyclophosphamide. This case suggested a possible association with chronic bacterial infection, which may play a role in the pathogenesis of ANCA-associated vasculitis.

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© 2004 by The Japanese Society of Internal Medicine
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