Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Infliximab is Effective for Takayasu Arteritis Refractory to Glucocorticoid and Methotrexate
Fumiko TanakaAtsushi KawakamiNozomi IwanagaMami TamaiYasumori IzumiKouichiro AratakeKazuhiko ArimaMakoto KamachiHideki NakamuraMingguo HuangHiroaki IdaTomoki OriguchiKatsumi Eguchi
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2006 Volume 45 Issue 5 Pages 313-316


We have experienced a Takayasu arteritis (TA) patient, successfully treated with infliximab, who did not respond well to conventional therapy with glucocosteroid and methotrexate. Takayasu arteritis had developed in a 24yearold woman (March 2003) who had been treated with glucocorticoid including methylprednisolone pulse therapy and methotrexate; however, she relapsed during the tapering of the dosage of oral prednisolone. Nineteen months after the first administration of glucocorticoid, 3 mg/kg of infliximab was introduced to the patient. The therapeutic efficacy of infliximab was markedly demonstrated; the patient's Creactive protein (CRP) value returned to almost normal range with subsequent tapering of the dosage of oral prednisolone in the absence of further relapse. This is the first case presentation of TA in Japan successfully treated with infliximab.

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© 2006 by The Japanese Society of Internal Medicine
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