Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
IgG4-related Autoimmune Prostatitis: Two Cases with or without Autoimmune Pancreatitis
Isao NishimoriTakuhiro KohsakiSaburo OnishiTaro ShuinShino KohsakiYasuhiro OgawaManabu MatsumotoMakoto HiroiHideaki HamanoShigeyuki Kawa
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2007 Volume 46 Issue 24 Pages 1983-1990


Recently, autoimmune pancreatitis (AIP) has been reported with a variety of extra-pancreatic manifestations and infiltration of IgG4-positive cells into the affected organs. We report herein two cases with prostatitis. One was seen in a patient with typical AIP, and the other was observed without any clinical manifestation of AIP. Serum IgG4 levels were elevated in both cases. Histological examination of the prostates showed that parenchymal cells were partially or totally replaced with fibrosis and abundant infiltration of IgG4-positive cells. Significant uptake of [18F] fluorodeoxyglucose by the prostate was seen in both cases. In the case with AIP, the uptake completely disappeared after steroid therapy. The findings observed in these cases suggest that the pathological mechanism for prostatitis is similar to the mechanism previously implicated in AIP, namely IgG4-related autoimmune prostatitis.

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© 2007 by The Japanese Society of Internal Medicine
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