Changes in the Urinary Excretion of β2-Microglobulin (β2MG) and N-acety-β-D-glucosaminidase (NAG) during Treatment for Lupus Nephritis

Takahiro Masuda; Tetsu Akimoto; Yasuhiro Ando; Takahisa Kobayashi; Daishi Meguro; Shigeaki Muto; Yoshihiko Ueda; Wako Yumura; Eiji Kusano

doi:10.2169/internalmedicine.47.0464

CASE REPORTS

Changes in the Urinary Excretion of β2-Microglobulin (β2MG) and N-acety-β-D-glucosaminidase (NAG) during Treatment for Lupus Nephritis

Takahiro Masuda, Tetsu Akimoto, Yasuhiro Ando, Takahisa Kobayashi, Daishi Meguro, Shigeaki Muto, Yoshihiko Ueda, Wako Yumura, Eiji Kusano

Author information

Takahiro Masuda
Division of Nephrology, Department of Internal Medicine, Jichi Medical University
Tetsu Akimoto
Division of Nephrology, Department of Internal Medicine, Jichi Medical University
Yasuhiro Ando
Division of Nephrology, Department of Internal Medicine, Jichi Medical University
Takahisa Kobayashi
Division of Nephrology, Department of Internal Medicine, Jichi Medical University
Daishi Meguro
Division of Nephrology, Department of Internal Medicine, Jichi Medical University
Shigeaki Muto
Division of Nephrology, Department of Internal Medicine, Jichi Medical University
Yoshihiko Ueda
Department of Pathology, Dokkyo Medical University Koshigaya Hospital
Wako Yumura
Division of Nephrology, Department of Internal Medicine, Jichi Medical University
Eiji Kusano
Division of Nephrology, Department of Internal Medicine, Jichi Medical University

Keywords: β2-microglobulin, N-acety-beta-D-glucosaminidase, lupus nephritis, tubulointerstitial nephritis, double filtration plasmapheresis

JOURNAL OPEN ACCESS

2008 Volume 47 Issue 4 Pages 287-290

DOI https://doi.org/10.2169/internalmedicine.47.0464

Details

Abstract

Tubulointerstitial involvement in the kidneys is frequently found but it is a less emphasized feature of lupus nephritis (LN). Recent studies have shown increases in the urinary excretion of β2-microglobulin (β2MG) and N-acetyl-beta-D-glucosaminidase (NAG), which are considered to indicate the presence of tubulointerstitial damage, particularly in cases of LN. However, the changes in these urinary parameters during the clinical course of LN have not yet been fully clarified. In this report, we describe the changes in the urinary excretion of β2MG and NAG during immunosuppressive treatment combined with double filtration plasmapheresis in a case of LN.

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