Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Successful Treatment of Chronic Myeloproliferative Disease-unclassifiable (CMPD-U) with No Chromosomal Abnormalities by Imatinib Mesylate
Satoshi IyamaTakuya MatsunagaTsutomu SatoKazuyuki MuraseNaoko ArakiRishu TakimotoMasayoshi KobuneTamotsu SagawaTetsuji TakayamaYoshiro Niitsu
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JOURNAL OPEN ACCESS

2008 Volume 47 Issue 8 Pages 791-794

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Abstract
We report a chronic myeloproliferative disease-unclassifiable (CMPD-U) patient who achieved hematological remission following imatinib mesylate (imatinib). Chromosomal and molecular analyses demonstrated no genetic abnormalities of c-abl, bcr-abl, c-kit or platelet-derived growth factor receptor (PDGFR) genes from hematopoietic cells. Although there has been one report of CMPD-U patient with chromosomal abnormalities of the PDGFR gene having complete hematologic responses upon treatment with imatinib, there have not been similar reports of patients without chromosomal abnormalities. This is the first case report of a CMPD-U patient with no chromosomal abnormalities who completely responded to treatment with imatinib.
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© 2008 by The Japanese Society of Internal Medicine
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