Brugada Syndrome Whose ST-segment Changes were Enhanced by Antihistamines and Antiallergenic Drugs

Motoki Matsuki; Nobuyuki Sato; Kanako Matsuda; Masaru Yamaki; Naoki Nakagawa; Naka Sakamoto; Hisanobu Ota; Yasuko Tanabe; Toshiharu Takeuchi; Kazumi Akasaka; Yuichiro Kawamura; Naoyuki Hasebe

doi:10.2169/internalmedicine.48.2067

CASE REPORTS

Brugada Syndrome Whose ST-segment Changes were Enhanced by Antihistamines and Antiallergenic Drugs

Motoki Matsuki, Nobuyuki Sato, Kanako Matsuda, Masaru Yamaki, Naoki Nakagawa, Naka Sakamoto, Hisanobu Ota, Yasuko Tanabe, Toshiharu Takeuchi, Kazumi Akasaka, Yuichiro Kawamura, Naoyuki Hasebe

Author information

Motoki Matsuki
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
Nobuyuki Sato
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
Kanako Matsuda
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
Masaru Yamaki
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
Naoki Nakagawa
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
Naka Sakamoto
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
Hisanobu Ota
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
Yasuko Tanabe
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
Toshiharu Takeuchi
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
Kazumi Akasaka
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
Yuichiro Kawamura
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College
Naoyuki Hasebe
Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College

Keywords: Brugada syndrome, antihistamines, antiallergenic drugs

JOURNAL OPEN ACCESS

2009 Volume 48 Issue 12 Pages 1009-1013

DOI https://doi.org/10.2169/internalmedicine.48.2067

Details

Abstract

We describe a case of Brugada syndrome, in which a coved type ST-segment elevation was enhanced by antihistamines and antiallergenic drugs. The patient had been treated with four kinds of antihistamines and antiallergenic drugs. The twelve-lead ECG exhibited a coved type ST-segment elevation in leads V₁ and V₂, and their enhancement was induced by pilsicainide. After discontinuing those drugs, the ST segment elevation in leads V₁ and V₂ became reduced. An ICD implantation was selected for the therapy since ventricular fibrillation was induced. Our report discusses the possible contribution of antihistamines and antiallergenic drugs to the Brugada type ST-segment changes.

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