Advanced Gastric Cancer Patient with Peritonitis Carcinomatosa Successfully Treated with a Combination Therapy of Paclitaxel and TS-1, but Relapsed with Multiple Bone Metastasis and Died from Rapidly Progressive Meningitis Carcinomatosa —Advanced Gastric Cancer with Metachronous Peritonitis Carcinomatosa and Meningitis Carcinomatosa—

Abstract

A 59-year-old man diagnosed as gastric cancer with peritonitis carcinomatosa was treated with paclitaxel and TS-1; 60 mg/m²/day of paclitaxel was given on days 1 and 8, and 60-80 mg/m²/day of TS-1 was given for 2 weeks. Six courses of combination therapy were administered, and the ascites disappeared completely. Because multiple bone metastases occurred, we attempted combination therapy with cisplatin and irinotecan hydrochloride; 50 or 30 mg/m²/day of cisplatin was given on day 1 or day 15, and 70 mg/m²/day of irinotecam hydrochloride was given on days 1 and 15. The patient achieved a remarkable response, however, intrameningeal dissemination occurred and he died from rapidly progressive meningitis carcinomatosa.