Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Acute Exacerbation of Idiopathic Pulmonary Fibrosis after Pandemic Influenza A (H1N1) Vaccination
Yukihiro UmedaMiwa MorikawaMasaki AnzaiYasuyuki SumidaMaiko KadowakiShingo AmeshimaTakeshi Ishizaki
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JOURNAL OPEN ACCESS

2010 Volume 49 Issue 21 Pages 2333-2336

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Abstract

We report a case of acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) after pandemic influenza (H1N1) vaccination. A 57-year-old man, who had been diagnosed with IPF in September 2008, was admitted to our hospital in December 2009 because of aggravation of dyspnea and fever two days after H1N1 vaccination. Chest computed tomography showed diffuse bilateral ground-glass opacities superimposed on preceding reticular opacities. We diagnosed AE-IPF. Corticosteroid and cyclophosphamide were effective. Although the efficacy of influenza vaccination in patients with chronic lung diseases is well established, physicians should keep in mind that influenza vaccination has the potential to cause AE-IPF.

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© 2010 by The Japanese Society of Internal Medicine
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