Case of Primary Biliary Cirrhosis-Autoimmune Hepatitis Overlap which Manifested after Delivery

Kyoko Monoe; Atsushi Takahashi; Fumiko Katsushima; Yukiko Kanno; Hironobu Saito; Kazumichi Abe; Junko Yokokawa; Hiromasa Ohira

doi:10.2169/internalmedicine.50.5022

CASE REPORTS

Case of Primary Biliary Cirrhosis-Autoimmune Hepatitis Overlap which Manifested after Delivery

Kyoko Monoe, Atsushi Takahashi, Fumiko Katsushima, Yukiko Kanno, Hironobu Saito, Kazumichi Abe, Junko Yokokawa, Hiromasa Ohira

Author information

Kyoko Monoe
Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
Atsushi Takahashi
Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
Fumiko Katsushima
Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
Yukiko Kanno
Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
Hironobu Saito
Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
Kazumichi Abe
Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
Junko Yokokawa
Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
Hiromasa Ohira
Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan

Keywords: autoimmune hepatitis, primary biliary cirrhosis, overlap, postpartum

JOURNAL OPEN ACCESS

2011 Volume 50 Issue 12 Pages 1299-1301

DOI https://doi.org/10.2169/internalmedicine.50.5022

Details

Abstract

A 34-year-old woman showed liver dysfunction for the first time at 3 months after delivery. Two years later, she was referred to our department with continued liver dysfunction. She fulfilled the criteria for primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap. Liver dysfunction improved after administration of ursodeoxycholic acid and bezafibrate. To the best of our knowledge this represents the second report of PBC-AIH overlap after delivery and we discuss immunological changes during the perinatal period.

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