A Case of Adult Autoimmune Hepatitis with Histological Features of Giant Cell Hepatitis

Hiroki Hayashi; Ryoichi Narita; Masaaki Hiura; Shintaro Abe; Akinari Tabaru; Akihide Tanimoto; Yasuyuki Sasaguri; Masaru Harada

doi:10.2169/internalmedicine.50.4063

CASE REPORTS

A Case of Adult Autoimmune Hepatitis with Histological Features of Giant Cell Hepatitis

Hiroki Hayashi, Ryoichi Narita, Masaaki Hiura, Shintaro Abe, Akinari Tabaru, Akihide Tanimoto, Yasuyuki Sasaguri, Masaru Harada

Author information

Hiroki Hayashi
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
Ryoichi Narita
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
Masaaki Hiura
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
Shintaro Abe
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
Akinari Tabaru
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
Akihide Tanimoto
Department of Pathology and Cell Biology, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
Yasuyuki Sasaguri
Department of Pathology and Cell Biology, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
Masaru Harada
Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan

Keywords: autoimmune hepatitis, giant cell hepatitis, keratin, Ki-67

JOURNAL OPEN ACCESS

2011 Volume 50 Issue 4 Pages 315-319

DOI https://doi.org/10.2169/internalmedicine.50.4063

Details

Abstract

Giant cell hepatitis is rare in adult patients. This form of hepatitis shows fast progression to cirrhosis. A 65-year-old woman was admitted to our hospital with jaundice. She was negative for hepatitis virus markers and positive for antinuclear antibodies. We diagnosed her as autoimmune hepatitis. Liver biopsy findings revealed typical features of interface hepatitis and giant cell hepatitis. Giant cells were positive for keratin 8/18, but not for keratin 19, keratin 7 or Ki-67. These results suggest that giant cell formation is associated with the fusion of matured hepatocytes rather than the active proliferation of immature cells.

Corresponding author

Register with J-STAGE for free!