Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
A Severe Form of Churg-Strauss Syndrome Complicated with Acute Cardiac Failure and Rapidly Progressive Peripheral Neuropathy -A Possible Effect of Intravenous Immunoglobulin Therapy
Daisuke KobayashiYoko WadaTakuma TakataToshiyuki KoyaShuichi MurakamiTakuya OzawaYoshifusa AizawaTakeshi KurodaMasaaki NakanoIchiei Narita
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JOURNALS OPEN ACCESS

2011 Volume 50 Issue 8 Pages 925-929

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Abstract

We report a case of Churg-Strauss syndrome (CSS) complicated by severe cardiac failure and peripheral neuropathy. Two courses of methylprednisolone pulse therapy were unable to control the disease activity. Repeated intravenous administration of high-dose human immunoglobulin (IVIg) was added together with intravenous cyclophosphamide pulse therapy (IVCY), and the patient's cardiac function and neurological symptoms were gradually ameliorated without any adverse event. Although glucocorticoid and cyclophosphamide comprise the standard therapy for patients with CSS, a number of patients with severe complications appear to be resistant to such conventional treatment. IVIg is thought to be an effective therapeutic option for such patients.

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© 2011 by The Japanese Society of Internal Medicine
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