Anaphylaxis due to Intravenous Levofloxacin with Tolerance to Garenoxacin

Kiyoharu Fukushima; Michiko Nakatsubo; Masahiro Noda; Takeshi Uenami; Yoshitomo Hayama; Naotoshi Tsuruta; Shuntaro Oniki; Yoshiyuki Saito; Takashi Niju; Toshiyuki Ikeda

doi:10.2169/internalmedicine.51.7530

CASE REPORTS

Anaphylaxis due to Intravenous Levofloxacin with Tolerance to Garenoxacin

Kiyoharu Fukushima, Michiko Nakatsubo, Masahiro Noda, Takeshi Uenami, Yoshitomo Hayama, Naotoshi Tsuruta, Shuntaro Oniki, Yoshiyuki Saito, Takashi Niju, Toshiyuki Ikeda

Author information

Kiyoharu Fukushima
Department of Internal Medicine, Nishinomiya Municipal Central Hospital, Japan
Michiko Nakatsubo
Department of Dermatology, Nishinomiya Municipal Central Hospital, Japan
Masahiro Noda
Department of Internal Medicine, Nishinomiya Municipal Central Hospital, Japan
Takeshi Uenami
Department of Internal Medicine, Nishinomiya Municipal Central Hospital, Japan
Yoshitomo Hayama
Department of Internal Medicine, Nishinomiya Municipal Central Hospital, Japan
Naotoshi Tsuruta
Department of Internal Medicine, Nishinomiya Municipal Central Hospital, Japan
Shuntaro Oniki
Department of Dermatology, Nishinomiya Municipal Central Hospital, Japan
Yoshiyuki Saito
Department of Internal Medicine, Nishinomiya Municipal Central Hospital, Japan
Takashi Niju
Department of Internal Medicine, Nishinomiya Municipal Central Hospital, Japan
Toshiyuki Ikeda
Department of Internal Medicine, Nishinomiya Municipal Central Hospital, Japan

Keywords: anaphylaxis, levofloxacin, cross reactions, fluoroquinolones, garenoxacin, hypersensitivity

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 13 Pages 1769-1772

DOI https://doi.org/10.2169/internalmedicine.51.7530

Details

Abstract

Fluoroquinolones are widely used in the management of infectious diseases, and are generally safe and well tolerated. However, immediate hypersensitivity reactions, including anaphylactic reactions, have been reported. We present here a case of anaphylactic shock in a 26-year-old man following intravenous levofloxacin administration. Skin tests confirmed an immediate hypersensitivity reaction to levofloxacin. Subsequent oral challenge tests for garenoxacin, which showed negative skin test results, confirmed that garenoxacin was well tolerated. This is the first report of tolerance to full-dose garenoxacin in a patient who developed an immediate hypersensitivity reaction to levofloxacin.

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