Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
Staphylococcal Enterotoxin B Toxic Shock Syndrome Induced by Community-acquired Methicillin-resistant Staphylococcus aureus (CA-MRSA)
Takeru KashiwadaKen KikuchiShinji AbeHidehito KatoHiroki HayashiTaisuke MorimotoKoichiro KamioJiro UsukiShinhiro TakedaKeiji TanakaKen'ichi ImanishiJunji YagiArata AzumaAkihiko Gemma
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Volume 51 (2012) Issue 21 Pages 3085-3088

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We herein report a case of toxic shock syndrome (TSS) associated with the 2009 pandemic H1N1 (pH1N1) influenza virus and a community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection in a 16-year-old Vietnamese girl. Staphylococcal enterotoxin B (SEB) was detected in the patient's serum, and the level of anti-SEB antibodies was found to be elevated. A flow cytometric analysis showed evidence of activated SEB-reactive Vβ3+ and Vβ12+ T cells. These data suggest that the CA-MRSA-induced activation of SEB-reactive T cells may cause TSS in patients with pH1N1 virus infection. Moreover, this is the first report describing immunological confirmation of SEB contributing directly to TSS in a patient fulfilling the diagnostic criteria of TSS.

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© 2012 by The Japanese Society of Internal Medicine
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