Anti-Glomerular Basement Membrane Glomerulonephritis Complicated by Thrombocytopenia

Takuya Miki; Tetsu Akimoto; Taro Sugase; Akihiko Numata; Naoko Otani; Yoshitaka Iwazu; Eri Takeshima; Yoshiyuki Morishita; Shigeaki Muto; Eiji Kusano

doi:10.2169/internalmedicine.51.8507

CASE REPORTS

Anti-Glomerular Basement Membrane Glomerulonephritis Complicated by Thrombocytopenia

Takuya Miki, Tetsu Akimoto, Taro Sugase, Akihiko Numata, Naoko Otani, Yoshitaka Iwazu, Eri Takeshima, Yoshiyuki Morishita, Shigeaki Muto, Eiji Kusano

Author information

Takuya Miki
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Tetsu Akimoto
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Taro Sugase
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Akihiko Numata
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Naoko Otani
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Yoshitaka Iwazu
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Eri Takeshima
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Yoshiyuki Morishita
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Shigeaki Muto
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Eiji Kusano
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan

Keywords: Anti-GBM glomerulonephritis, crescent, heparin-induced thrombocytopenia, thrombotic microangiopathy, plasma exchange

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 24 Pages 3395-3399

DOI https://doi.org/10.2169/internalmedicine.51.8507

Details

Abstract

Rapidly progressive glomerulonephritis (RPGN) is characterized by the rapid deterioration of the renal function associated with crescent formation on renal biopsies. This report describes a case of RPGN caused by anti-glomerular basement membrane (GBM) glomerulonephritis in an elderly man with severe thrombocytopenia and a platelet count of 1.4×10⁴/μL. Thrombotic microangiopathy (TMA) and heparin-induced thrombocytopenia (HIT) were implicated in the severe decrease in platelets. This report also discusses the pathological background and clinical management of TMA and HIT among patients with anti-GBM glomerulonephritis.

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