Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
The Need for Continuing Chemotherapy for Leukemic Cell Lysis Pneumopathy in Patients with Acute Myelomonocytic/Monocytic Leukemia
Aiko KatoYuichiro OnoYosuke NagahataNobuhiko YamauchiSumie TabataNoboru YonetaniAkiko MatsushitaTakayuki Ishikawa
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JOURNALS OPEN ACCESS

2013 Volume 52 Issue 11 Pages 1217-1221

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Abstract

Although fatal pulmonary complications frequently occur during the course of acute leukemia, a minor proportion of the complications are due to leukemia itself. Infections, drug reactions and concomitant medical conditions are the major causes of respiratory distress in leukemic patients. We treated four patients with acute myeloid leukemia complicated by leukemic cell lysis pneumopathy (LCLP). All of the patients had leukemia of monocytoid origin and their respiratory function deteriorated soon after chemotherapy initiation. Although two of the patients required mechanical ventilation, all four improved after continued chemotherapy. Our experience indicates that, in cases of LCLP, chemotherapy should be continued with maximal respiratory support.

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© 2013 by The Japanese Society of Internal Medicine
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