Acute Post-streptococcal Glomerulonephritis with Acute Kidney Injury in Nephrotic Syndrome with the Glomerular Deposition of Nephritis-associated Plasmin Receptor Antigen

Ayako Kokuzawa; Yoshiyuki Morishita; Hiromichi Yoshizawa; Kana Iwazu; Takanori Komada; Tetsu Akimoto; Osamu Saito; Takashi Oda; Fumi Takemoto; Yasuhiro Ando; Shigeaki Muto; Wako Yumura; Eiji Kusano

doi:10.2169/internalmedicine.52.0103

CASE REPORTS

Acute Post-streptococcal Glomerulonephritis with Acute Kidney Injury in Nephrotic Syndrome with the Glomerular Deposition of Nephritis-associated Plasmin Receptor Antigen

Ayako Kokuzawa, Yoshiyuki Morishita, Hiromichi Yoshizawa, Kana Iwazu, Takanori Komada, Tetsu Akimoto, Osamu Saito, Takashi Oda, Fumi Takemoto, Yasuhiro Ando, Shigeaki Muto, Wako Yumura, Eiji Kusano

Author information

Ayako Kokuzawa
Division of Rheumatology and Clinical Immunology, Jichi Medical University, Japan
Yoshiyuki Morishita
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Hiromichi Yoshizawa
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Kana Iwazu
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Takanori Komada
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Tetsu Akimoto
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Osamu Saito
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Takashi Oda
Department of Nephrology, National Defense Medical College, Japan
Fumi Takemoto
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Yasuhiro Ando
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Shigeaki Muto
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Wako Yumura
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan
Eiji Kusano
Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan

Keywords: acute post-streptococcal glomerulonephritis, acute kidney injury, nephrotic syndrome, nephritis-associated plasmin receptor (NAPlr)

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 18 Pages 2087-2091

DOI https://doi.org/10.2169/internalmedicine.52.0103

Details

Abstract

We herein report the case of a 17-year-old man who developed an increased plasma creatinine level (11.1 mg/dL) and oliguria with massive proteinuria (27.3 g/day) four weeks after an abraded wound to his right knee. The histology of the renal biopsy specimens showed diffuse endocapillary proliferative glomerulonephritis with the deposition of nephritis-associated plasmin receptor in the glomerulus. A case of acute kidney injury due to nephrotic syndrome caused by acute post-streptococcal glomerulonephritis was diagnosed. His renal function and proteinuria were improved with supportive care, including hemodialysis, without the administration of immunosuppressive agents.

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