Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Basal Ganglia Hyperintensity on T1-weighted Imaging of a Patient with Central Nervous System Metastasis Producing Carcinoembryonic Antigens
Koji FujitaWaka SakaiMasafumi HaradaMika SakakiHideo MureShinji NagahiroYuishin IzumiRyuji Kaji
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JOURNALS OPEN ACCESS

2013 Volume 52 Issue 3 Pages 381-383

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Abstract

We herein report unusual basal ganglia hyperintense lesions on noncontrast T1-weighted magnetic resonance imaging in a patient with central nervous system metastasis from lung adenocarcinoma that was treated with gefitinib. T2*-weighted magnetic resonance imaging showed no hypointense lesions, thereby excluding the possibility of calcification or haemorrhage. A stereotactic brain biopsy of the left basal ganglia lesions revealed atypical cells, some of which formed a glandular lumen with a micropapillary pattern. These cells were immunopositive for markers of lung adenocarcinoma, thereby confirming the diagnosis of metastasis. We speculate that proteins, including carcinoembryonic antigens from the adenocarcinoma cells in the basal ganglia, may have contributed to the hyperintensity observed on noncontrast T1-weighted magnetic resonance imaging.

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© 2013 by The Japanese Society of Internal Medicine
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