2014 Volume 53 Issue 18 Pages 2127-2131
Most human immunodeficiency virus (HIV)-related lymphomas are of B-cell origin, and the T-cell type is very rare. We experienced a Japanese case of HIV-associated peripheral T-cell lymphoma (HIV-PTCL). Sudden intestinal hemorrhage necessitated emergent surgical resection of the small intestine, in which an ulcerative lesion was detected. A histopathological examination revealed large tumor cells in the base of the ulcer, which were immunohistochemically CD30+, CD56+, granzyme B+, CD3+ (focally), CD4-, CD8- and EBER+. A diagnosis of PTCL, not otherwise specified, was therefore made. The differential diagnosis and significance of Epstein-Barr virus infection are also herein discussed.