Gastric Mixed Adenoneuroendocrine Carcinoma with a Good Prognosis

Nobuhiko Fukuba; Takafumi Yuki; Shunji Ishihara; Hiroki Sonoyama; Yasumasa Tada; Ryusaku Kusunoki; Akihiko Oka; Naoki Oshima; Ichiro Moriyama; Kousaku Kawashima; Yoshikazu Kinoshita

doi:10.2169/internalmedicine.53.3328

CASE REPORTS

Gastric Mixed Adenoneuroendocrine Carcinoma with a Good Prognosis

Nobuhiko Fukuba, Takafumi Yuki, Shunji Ishihara, Hiroki Sonoyama, Yasumasa Tada, Ryusaku Kusunoki, Akihiko Oka, Naoki Oshima, Ichiro Moriyama, Kousaku Kawashima, Yoshikazu Kinoshita

Author information

Nobuhiko Fukuba
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Takafumi Yuki
Division of Gastrointestinal Endoscopy, Shimane University Hospital, Japan
Shunji Ishihara
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Hiroki Sonoyama
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Yasumasa Tada
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Ryusaku Kusunoki
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Akihiko Oka
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Naoki Oshima
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Ichiro Moriyama
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Division of Cancer Center, Shimane University Hospital, Japan
Kousaku Kawashima
Department of Internal Medicine II, Shimane University School of Medicine, Japan
Yoshikazu Kinoshita
Department of Internal Medicine II, Shimane University School of Medicine, Japan

Keywords: gastric cancer, good prognosis, mixed adenoneuroendocrine carcinoma

JOURNAL OPEN ACCESS

2014 Volume 53 Issue 22 Pages 2585-2588

DOI https://doi.org/10.2169/internalmedicine.53.3328

Details

Abstract

A flat, elevated lesion measuring 5 mm in diameter was found in the gastric body of an 80-year-old man. A biopsy showed moderately differentiated adenocarcinoma, and endoscopic ultrasonography revealed a hypoechoic mass located in the submucosa. Endoscopic submucosal dissection was subsequently performed, and a pathological examination revealed a tumor composed of adenocarcinoma and neuroendocrine carcinoma with submucosal infiltration. The pathological diagnosis was gastric mixed adenoneuroendocrine carcinoma (MANEC). An additional gastrectomy procedure was performed, and no recurrence was noted for at least three years. This case is interesting with respect to the carcinogenesis of endocrine cell carcinoma and MANEC.

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