Gastric Diffuse Large B-cell Lymphoma Cured with Helicobacter pylori Eradication Regardless of Whether it Contains Features of MALT Lymphoma

Kei Mitsuhashi; Kentaro Yamashita; Akira Goto; Takeya Adachi; Yoshihiro Kondo; Kiyoshi Kasai; Ryo Suzuki; Mayuko Saito; Yoshiaki Arimura; Yasuhisa Shinomura

doi:10.2169/internalmedicine.53.1603

CASE REPORTS

Gastric Diffuse Large B-cell Lymphoma Cured with Helicobacter pylori Eradication Regardless of Whether it Contains Features of MALT Lymphoma

Kei Mitsuhashi, Kentaro Yamashita, Akira Goto, Takeya Adachi, Yoshihiro Kondo, Kiyoshi Kasai, Ryo Suzuki, Mayuko Saito, Yoshiaki Arimura, Yasuhisa Shinomura

Author information

Kei Mitsuhashi
Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Japan
Department of Gastroenterology, Otaru City General Hospital, Japan
Kentaro Yamashita
Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Japan
Akira Goto
Department of Gastroenterology, Otaru City General Hospital, Japan
Takeya Adachi
Department of Gastroenterology, Otaru City General Hospital, Japan
Yoshihiro Kondo
Department of Gastroenterology, Otaru City General Hospital, Japan
Kiyoshi Kasai
Department of Clinical Pathology, Otaru City General Hospital, Japan
Ryo Suzuki
Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Japan
Mayuko Saito
Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Japan
Yoshiaki Arimura
Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Japan
Yasuhisa Shinomura
Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Japan

Keywords: gastric lymphoma, diffuse large B-cell lymphoma, mucosa-associated lymphoid tissue lymphoma, Helicobacter pylori, eradication

JOURNAL OPEN ACCESS

2014 Volume 53 Issue 7 Pages 695-698

DOI https://doi.org/10.2169/internalmedicine.53.1603

Details

Abstract

A 66-year-old patient was diagnosed with primary gastric B-cell lymphoma. The pathological findings were consistent with diffuse large B-cell lymphoma (DLBCL); however, a small area showed features of mucosa-associated lymphoid tissue (MALT) lymphoma. Biopsy specimens were referred to two other pathologists, both of whom diagnosed the case as pure DLBCL, denying the area of MALT lymphoma. As the lymphoma was limited to the submucosal layer and the patient's general condition was excellent, eradication of Helicobacter pylori was selected as the initial treatment. The lymphoma completely disappeared three months after the eradication treatment, and complete remission has been maintained for nearly two years.

Corresponding author

Register with J-STAGE for free!