Treatment of Mediastinitis due to Methicillin-resistant Staphylococcus aureus in a Renal Dysfunction Patient Undergoing Adjustments to the Linezolid Dose

Yasuhiro Tsuji; Masato Tashiro; Nobuyuki Ashizawa; Yukio Ota; Hayato Obi; Saori Nagura; Munetoshi Narukawa; Kazuaki Fukahara; Naoki Yoshimura; Hideto To; Yoshihiro Yamamoto

doi:10.2169/internalmedicine.54.2292

CASE REPORTS

Treatment of Mediastinitis due to Methicillin-resistant Staphylococcus aureus in a Renal Dysfunction Patient Undergoing Adjustments to the Linezolid Dose

Yasuhiro Tsuji, Masato Tashiro, Nobuyuki Ashizawa, Yukio Ota, Hayato Obi, Saori Nagura, Munetoshi Narukawa, Kazuaki Fukahara, Naoki Yoshimura, Hideto To, Yoshihiro Yamamoto

Author information

Yasuhiro Tsuji
Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
Masato Tashiro
Department of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
Nobuyuki Ashizawa
Department of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
Yukio Ota
Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
Hayato Obi
Department of Surgery, Graduate School of Medicine, University of Toyama, Japan
Saori Nagura
Department of Surgery, Graduate School of Medicine, University of Toyama, Japan
Munetoshi Narukawa
Department of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
Kazuaki Fukahara
Department of Surgery, Graduate School of Medicine, University of Toyama, Japan
Naoki Yoshimura
Department of Surgery, Graduate School of Medicine, University of Toyama, Japan
Hideto To
Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan
Yoshihiro Yamamoto
Department of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan

Keywords: linezolid, mediastinitis, methicillin-resistant Staphylococcus aureus, renal dysfunction, therapeutic drug monitoring

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 2 Pages 235-239

DOI https://doi.org/10.2169/internalmedicine.54.2292

Details

Abstract

This study is the first case report of the treatment of methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis using therapeutic drug monitoring of the serum and wound exudate concentrations of linezolid in a renal dysfunction patient. In the present study, the serum trough concentration of linezolid was maintained between 2 and 7 μg/mL. Therapeutic drug monitoring dosage adjustments may be especially useful in patients with renal dysfunction and severe MRSA infection.

Corresponding author

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